Extracting basic drugs in biological fluids


C8/SCX is composed of silica gel bonded with octyl and phenylsulfonic acid groups at a specific ratio. It’s a mixed-mode sorbent with two retention mechanisms: octyl groups provide moderately hydrophobic interactions, phenylsulfonic acid groups provide strong cation exchange

C8/SCX will be a better choice if very strong adsorption in C18, C8 or SCX packing results in difficult elution of some analytes.



  • Moderate retention, avoiding extremely strong adsorption of some compounds
  • Ideal for complicated samples such as blood and urine



Surface area: 510 m 2/g
Particle size: 40 - 75 μm
Pore size: 70 Å



  • Determination of drugs and their metabolites in biological fluids
  • Determination of drugs of abuse such as cocaine, acetylcodeine, morphine and ketamine

C8/SCX SPE Cartridges


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