Extracting acidic drugs in biological fluids


C8/SAX is composed of silica gel bonded with octyl and quaternary ammonium groups at a specific ratio. It’s a mixed-mode sorbent with two retention mechanisms: octyl groups provide moderately hydrophobic interactions, quaternary ammonium groups provide strong anion exchange

C8/SAX will be a better choice if very strong adsorption in C18, C8 or SAX packing results in difficult elution of some analytes.



  • Moderate retention, avoiding extremely strong adsorption of some compounds
  • Ideal for complicated samples such as blood and urine



Surface area: 510 m 2/g
Particle size: 40 - 75 μm
Pore size: 70 Å



  • Determination of drugs and their metabolites in biological fluids, such as barbiturates
  • Determination of drugs of abuse such as THC

C8/SAX SPE Cartridges


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